Cyber-physical systems are characterized by strong interactions between their physical and computation parts. The increasing complexity of such systems, now used in numerous application domains (e.g., aeronautics, healthcare), in conjunction with hard to predict surrounding environments or the use of non-traditional middleware and with the presence of non-deterministic or non-explainable software outputs, tend to make traditional Verification and Validation (V&V) techniques ineffective. This paper presents the H2020 ADVANCE project, which aims precisely at addressing the Verification and Validation challenges that the next-generation of cyber-physical systems bring, by exploring techniques, methods and tools for achieving the technical objective of improving the overall efficiency and effectiveness of the V&V process. From a strategic perspective, the goal of the project is to create an international network of expertise on the topic of V&V of cyber-physical systems.